A Tulane University study published in the Journal of Alzheimer’s Disease threw light on how high-blood pressure (like in Type 2 diabetes) raises substantially the toxicity of the beta amyloid protein associated with Alzheimer’s disease. These toxins prove fatal to cells lining blood vessels in the brain, and the vascular damage may contribute to dementia.
Dr. David Busija, Regents Professor and Chair of pharmacology at Tulane University School of Medicine, stated- “Previously, it was believed that Alzheimer’s disease was due to the accumulation of ‘tangles’ in neurons in the brain from overproduction and reduced removal of beta amyloid protein. While neuronal involvement is a major factor in Alzheimer’s development, recent evidence indicates damaged cerebral blood vessels compromised by high blood sugar play a role. Even though the links among Type 2 diabetes, brain blood vessels and Alzheimer’s progression are unclear, hyperglycemia appears to play a role.”